Endocrine Abstracts

Introduction: Acromegaly with GH excess affects up to 20% of the patients with McCune–Albright syndrome (MAS). Surgical treatment for acromegaly in MAS is often difficult because of skull-base dysplasia. Somatostatin analogs are frequently only partially effective and GH receptor antagonist – pegvisomant is more potent in normalizing IGFI levels. Radiotherapy is controversial. Pregnancy in MAS patients is described in literature but no case of successful delivery in ...

Acromegaly is usually diagnosed after several years of duration. The multimodal therapy – surgery, radiotherpy, pharmacotherapy – is necessary in the majority of patients. Register of sellar tumors (RESET) collecting data of patients from eight tertiary centers in the Czech and Slovak Republics since the year 2000 was established in 2008.Aim of analysis: Evaluation of diagnostics of acromegaly and effectiveness of its treatment in a daily pract...